US surgeons successfully test pig kidney transplant in a human patient

First, the kidneys implanted in the human body are not immediately responded to by the immune system, great freedom that can eventually help to reduce the scarring of human organs for conversion.

Procedures at NYU Langone Health in New York City include the use of pigs that alter their genetic makeup so that their meat does not have molecules that trigger immediate reactions.

The recipient was a brain-dead patient with kidney function that his family believed in the evidence before he was taken off life support, the researchers told Reuters.

For three days, the new kidney was tied to her blood vessels and placed outside her body, allowing the researchers to enter.

The results of a kidney transplant test “appear to be fine,” says surgeon Dr. Robert Montgomery, who conducted the study, said.

The kidneys produced “the amount of urine you would expect” from a kidney turned into a human, he said, with no evidence of severe stiffness, the former being rejected when the kidneys were incorrectly rotated in non-human animals.

The receptor’s abnormal creatinine level, a sign of kidney failure, returned to normal when ingested, Montgomery said.

In the United States, nearly 107,000 people are awaiting organ transplants, including more than 90,000 kidney transplants, according to the United Network for Organ Sharing. Wait a time for the kidneys of three to five years.

Researchers have been working for decades on the possibility of using animal parts to replicate, but are being harassed about how to prevent rejection of the human body right away.

Montgomery’s team devised a breakdown of pig cells for the carbohydrate that triggers the breakdown, a molecule of sugar, or glucan, called alpha-gal, that would avoid the problem.

A genetically modified pig gene, called GalSafe, was developed by Revivicor United Therapeutics Corp (UTHR.O). The US Food and Drug Administration approved it in December 2020, for use as a food for people with skin allergies and where humane treatment is available.

Pig health products will still need FDA approval directly before being used in humans, the company said.

Other researchers are considering whether GalSafe pigs could be the source of everything from heart valves to feces for human patients.

The New York University kidney transplant trial should pave the way for testing in patients with kidney failure, perhaps in the next year or two, Montgomery said, a heart transplant himself. Trials can test the method as a short-term solution for critically ill patients until the kidney is permanent or as a permanent cast.

The current test involves a single rotation and the kidney lasts only three days, so any future testing will reveal new hurdles that will need to be overcome, Montgomery said. Participants will be patients less likely to receive a human kidney and with a negative prognosis on dialysis.

“For many of them, the death rate is too high for certain cancers, we don’t think twice about using new drugs and doing new experiments (with cancer patients) when it can give them months and how much then life, ”Montgomery said.

The researchers worked with healthcare professionals, attorneys, and attorneys to brainstorm the idea before asking the family to search for a patient with temporary brain death, Montgomery said.